Yes. Here's the take of the Mayo Clinic: "The Use of vitamin E can interact with many conditions. For example, research suggests that oral use of vitamin E might increase the risk of prostate cancer. Other research suggests that vitamin E use might increase the risk of death in people with a severe history of heart disease, such as heart attack or stroke. Talk with your doctor before taking vitamin E if you have:

A vitamin K deficiency

An eye condition in which the retina is damaged (retinitis pigmentosa)

Bleeding disorders

Diabetes

A history of a previous heart attack or stroke

Head and neck cancer

Liver disease

The supplement might increase your risk of bleeding. If you're planning to have surgery, stop taking vitamin E two weeks beforehand. Also, talk to your doctor about vitamin E use if you're about to have or you just had a procedure to open blocked arteries and restore normal blood flow to your heart muscle (angioplasty)."

Wow!